Cholangiocarcinoma, clonorchiasis, clonorchis sinensis. The basic imaging finding of clonorchiasis is diffuse dilatation of the peripheral intrahepatic bile ducts, without dilation of the large. This segregation is consistent with the broader natural distribution of the two species. Clonorchis sinensis was named after that the worm was discovered in the bile duct of a chinese carpenter in calcutta, a harbor city of india, in 1874. Clonorchis merupakan anggota dari trematoda platyhelminthes. Cdc clonorchis biology centers for disease control. Prevalence and intensity of clonorchis sinensis metacercariae in. Nevertheless, they are often underestimated compared to other, better known neglected diseases in spite of the fact that many millions of humans are infected and hundreds of millions at risk. Dogs and cats are the most important reservoir hosts. It was discovered by a british physician james mcconnell at the medical college hospital in calcutta kolkata in 1874. Clonorchiasis, clonorchis sinensis, diagnosis, pathogenesis, omics, prevention. China, especially in the northeastern provinces of heilongjiang and jilin ministry of health china, 2005, as well as in neighbouring regions of both north and south korea hotez, 2003. Production and deformation of clonorchis sinensis eggs during in.
Clonorchis sinensis, the chinese or oriental liver fluke, is an important human parasite and is widely distributed in southern korea, china including taiwan, japan, northern vietnam and the far eastern part of russia. Clonorchiasis is an infectious disease caused by the chinese liver fluke, clonorchis sinensis, and two related species. Clonorchis sinensis ova in bile juice cytology from a. Trematode parasites of the genera clonorchis, opisthorchis and metorchis, commonly referred to as liver flukes, are transmitted to humans and other mammals by the ingestion of fish infected with their larval stages which. Clonorchis sinensis, the chinese liver fluke, is a liver fluke belonging to the class trematoda, phylum platyhelminthes. Although man is the main host, the parasite also infects cats, dogs and other fisheating carnivores which probably serve as reservoirs of human infection. The chinese liver fluke clonorchis opisthorchis sinensis is widely distributed in the far east. Hepatitis b and c virus, clonorchis sinensis for the risk of liver cancer. Clonorchiasis adalah penyakit menahun yang menyerang bagian saluran antara hati dan empedu, disebabkan oleh cacingcacing clonorchis sinensis. Clonorchis sinensis, the etiological agent of clonorchiasis, is the most endemic fishborne zoonotic liver fluke that causes a heavy socioeconomic burden in south asia 1. An enzymelinked immunosorbent assay elisa was developed to replace the usual intradermal test, and its performance in an area of endemicity was evaluated.
The human and animal reservoir hosts dogs, pigs, cats and rats acquire the. Symptoms of clonorchiasis are related to worm burden. Cacing clonorchis atau chinese liver fluke atau clonorchis sinensis hidup dalam hati manusia, daur hidupnya hampir sama dengan fasciola, hanya inang perantaranya adalah ikan air tawar. Department of pathology and bacterilogy, university of hong kong. Approximately 35 million people are infected with c. Eating raw or halfcooked fresh water fish and shrimps human liver fluke disease clonorchis and opistorchis are quite similar causing similar disease. Manusia terinfeksi melalui makanan ikan tawar mentah yang mengandung kista cacing tersebut. Nama lain parasit ini adalah opisthorchis sinensis atau the chinese liver fluke. Pdf hepatitis b and c virus, clonorchis sinensis for the.
Infection with the trematode clonorchis sinensis is the most common human fluke infection in east asian populations. Pubmed journal articles for clonorchis sinensis were found in prime pubmed. Immunological analysis of opisthorchis and clonorchis. Clonorchiasis occurs in all parts of the world where there are asian immigrants from endemic areas. We would like to show you a description here but the site wont allow us. Performance of an enzymelinked immunosorbent assay for. Free publisher full textpmc free full textpmc free pdf. The relationship between primary carcinoma of the liver. Clonorchis sinensis is still a common parasite in south korea. Current status of clonorchis sinensis and clonorchiasis in. Clonorchis sinensis, opisthorchis viverrini, and o. Clonorchis sinensis, also known as the chinese liver fluke, belongs to the family opisthorchiidae, and is one of the most important foodborne parasites, endemic in eastern asian countries, including china, korea, vietnam, thailand and the far east regions of russia.
Clonorchis sinensis opisthorchis viverrini and clonorchis sinensis were considered by a previous iarc working group in 1994 iarc, 1994. The pathology of clonorchis sinensis infestation of the liver pao. Clonorchis sinensis is a fishborne trematode that inhabits the bile duct of mammals including humans. Clonorchiasis is a known risk factor for the development of cholangiocarcinoma, a neoplasm of the biliary system. Clonorchis sinensis introduction clonorchis sinensis, also known as the chinese liver fluke is a narrow elongate liver fluke found in the far east. The infection status of clonorchis sinensis metacercariae csmc was examined in freshwater fish from a highly prevalent site, wicheon a.
Clonorchis sinensis, opisthorchis spp, and metorchis spp. Clonorchiasis, or chinese liver fluke disease, is caused by infection with clonorchis sinensis. Pdf changes in sonographic findings after treatment of. Clonorchis sinensis, an oriental liver fluke, as a human biological. Linking to a nonfederal website does not constitute an endorsement by cdc or any of its employees of the sponsors or the information and products presented on the website.
Chang department of pathology, university of hong kong. This fluke is quite common in china, japan, korea, taiwan and vietnam among others. Humans become infected by eating raw, undercooked, dried, salted, or pickled fish. To improve the rate of detection of clonorchis sinensis infection, we compared different specimens from patients with cholecystolithiasis. Dpdx is an educational resource designed for health professionals and laboratory scientists. Current status and perspectives of clonorchis sinensis and. Clonorchiasis is a common infection of dogs and other fisheating carnivores reservoir final hosts in china, the democratic peoples republic of korea, the republic of korea and viet nam.
Clonorchis sinensis infestation promotes threedimensional. Links with this icon indicate that you are leaving the cdc website the centers for disease control and prevention cdc cannot attest to the accuracy of a nonfederal website. Clonorchis sinensis the oriental or chinese liver fluke clonorchis sinensis adult clonorchis sinensis egg 1. Since that time, new data have become available, these have been incorporated in the monograph, and taken into consideration in the present evaluation. Clonorchis sinensis an overview sciencedirect topics. Clonorchiasis wikipedia bahasa indonesia, ensiklopedia bebas.
Clonorchiasis is infection with the liver fluke clonorchis sinensis. Clonorchis sinensis, dipylidium caninum, dan toxocara cati bersifat zoonotik. Clonorchis sinensis is the major liver fluke found in p. Clonorchis sinensis infection, but that detecting igm antibody had not. Prime pubmed clonorchis sinensis journal articles from pubmed.
Clonorchis sinensis introduction to medical parasitology. In humans, it infects the common bile duct and gall bladder, feeding on bile. Humans become infected by eating raw, undercooked, dried, salted, or pickled fish containing encysted metacercariae. Low divergence of clonorchis sinensis in china based on. Although this infection is associated with obstructive jaundice or choledocholithiasis, portal vein thrombosis has not been reported. Clonorchis sinensis is known to be widely distributed in northern provinces, whereas o. Identification and characterization of clonorchis sinensis cathepsin. Clonorchiasis is a common disease in china, vietnam, korea, and japan and is acquired by. Microscopic examination of gallbladder stones improves. Clonorchis sinensis and clonorchiasis pdf free download. Human eats undercooked fish containing the metacercaria. The trematode clonorchis sinensis chinese or oriental liver fluke is an important foodborne pathogen and cause of liver disease in asia. In 1874, a 20 year old chinese carpenter was admitted to the medical college hospital.
Infection is acquired by eating undercooked freshwater fish. The relationship between primary carcinoma of the liver and infestation with clonorchis sinensis hou pao. Immunological analysis of opisthorchis and clonorchis antigens volume 64 issue 2 s. Diagnosis is by identifying eggs in the feces or duodenal contents. Cacing dewasa meletakkan telurtelurnya di dalam saluran empedu yang dikeluarkan tubuh melalui kotoran. Key method a total of 347 residents showed positive stool results for clonorchis sinensis eggs in a village in northeastern china, and were treated with praziquantel. During the 2 past decades, many reports regarding imaging findings of clonorchiasis were introduced. Untuk menghindari penyakit ini, masaklah ikan air tawar secara sempurna karena jika terkena penyakit ini akan menyebabkan kerusakan hati yang. Clonorchiasis is an important foodborne trematodiases in asia, caused by chronic infection with clonorchis sinensis 1, 2. The pathology of clonorchis sinensis infestation of the liver. The kits detecting igg antibody also showed high sensitivity in heavy infection intensity. It parasitises the biliary duct in humans who become infected by eating raw or undercooked fish.
Among several diagnostic tools for clonorchiasis clonorchis sinensis infection, radiologic examinations are commonly used in clinical practices. Human clonorchiasis is a prevailing foodborne disease caused by clonorchis sinensis infection. Clonorchis sinensis family opisthorchiidae is an important foodborne parasite that has a major socioeconomic impact on 35 million people predominantly in china, vietnam, korea and the russian. Trematode parasites of the genera clonorchis, opisthorchis and metorchis, commonly referred to as liver flukes, are transmitted to humans and other mammals by the ingestion of fish infected with their larval stages which ultimately come from snails infected due to excreta. Infection is usually acquired by eating undercooked freshwater fish. Feces, gallbladder bile, and gallbladder stones collected from 179 consecutive patients with cholecystolithiasis underwent microscopic examination, and according to the results, 30 eggpositive and 30 eggnegative fecal, gallbladder bile, and. Clonorchis sinensis adalah salah satu trematoda hati yang bersifat hermaprodit yang dapat menimbulkan penyakit clonorchiasis. Images in clinical medicine from the new england journal of medicine clonorchis sinensis. Clonorchis wikipedia bahasa indonesia, ensiklopedia bebas.
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